Context: Asthma is chronic inflammatory disorder of the respiratory system in childhood. IgE has an important role in allergic disorders such as asthma. The aim of this study is to review the association between maternal serum IgE and incidence of childhood asthma. Evidence Acquisition: Three researchers searched all articles in PubMed, Scopus, Google and Embase databases related to maternal serum IgE, cord blood IgE, childhood asthma and incidence using key words such as maternal IgE, cord blood IgE, relation, association, childhood asthma, child allergy. Results: We found a few related articles on the topic of maternal IgE, cord blood IgE, and childhood asthma. We reviewed 11 articles for this study. Parental atopy and allergy are more important predictive factors for children’ s allergies such as asthma. IgE levels was higher in children whose mothers had higher IgE levels. Total IgE level was significantly higher in boys compared to girls. Conclusions: Increasing maternal and cord blood IgE may be a predictive factor for development of children asthma. More data is needed to clearify this relation.

Background: There are three broad types of food allergies, including IgE-mediated reactions, non-IgE-mediated reactions, and mixed reactions. The onset of IgE-mediated food allergies is usually rapid and can sometimes lead to serious illness. Non-IgEmediated and mixed types of food allergies can cause significant morbidity as a result of chronic disease. Objectives: This study aimed to compare various types of food allergies and discuss the basis of their different presentations. Methods: This study was conducted on children aged 2-12 years old with signs or symptoms of food allergy in the allergy clinics of Azad University Hospitals, Tehran, Iran, from January 2019 to January 2020. Food allergy was evaluated in these patients by careful history, physical exam, skin prick test, and atopy patch test. Results: A positive family history of atopy was detected in the first-degree relatives of 82 (63%) patients. All the children were exclusively breastfed at the beginning. A total of 61 patients had positive skin prick test (SPT), and 68 patients had positive atopy patch test (APT) results. Among food allergens, a significant correlation was detected between positive atopic patch test results and hypersensitivity reactions to cow’, s milk (P value = 0. 001), beef (0. 002), and tomato (0. 04). There was the same significant correlation between positive skin prick test results, allergens, and wheat (P value = 0. 01). Conclusions: Although skin prick and atopy patch tests may help identify the culprit foods, oral food challenges are the mainstay of the diagnosis.

Mashhad University of medical sciences Mashhad Iran CD23, the low affinity receptor for IgE (FCε R II), functions as a multifunctional regulator of immune system and IgE synthesis, in part, by producing an IgE binding factor (soluble CD23). Objectives: To evaluate the serum levels of total IgE and soluble CD23 (sCD23) in the atopic patients and to determine whether there is any correlation between these markers. Method: Forty-five adult atopic subjects (allergic rhinitis 17, allergic asthma 17 and atopi dermatitis 11) with positive skin prick test to common allergens and positive family history of atopy were entrolled in a case-control study. Serum levels of total IgE and sCd23 of these subjects were measured by ELISA controls. Results: Mean age and sex ratio were similar among study groups. Mean serum levels of sCD23 in atopic groups (5.12±3.9ng/ml) were significantly higher than control group (0.2ng/ml) (P<0.01). Mean total IgE level in atopic groups and control group were 388±204 IU/ml, 43±40 IU/ml respectively. Atopic subjects had significantly higher IgE level (P<0.01). There were no correlations between serum levels of total IgE and sCD23. Conclusion: sCD23 maybe a good atopy prediction marker.